Which sequence correctly represents the development of mature ova?

Which sequence correctly represents the development of mature ova?

• A. Primordial follicle → primary → secondary → antral → mature → corpus luteum → corpus albicans
• B. Primary → primordial → secondary → mature → corpus albicans → corpus luteum → antral
• C. Primordial → secondary → primary → antral → mature → corpus albicans → corpus luteum
• D. Antral → primordial → primary → secondary → mature → corpus luteum → corpus albicans

Answer: (A)

Ovarian follicle development occurs in a numbered sequence that moves from a resting primordial follicle to progressively more mature structures, followed by ovulation and then luteal formation and eventual regression. A primordial follicle houses an oocyte arrested in prophase I and is encased by a single layer of flat granulosa cells. It matures into a primary follicle with a single layer of cuboidal granulosa cells and the beginnings of the zona pellucida. The next stage is the secondary (pre-antral) follicle, where granulosa cells proliferate and thecal cells start to appear. When a fluid-filled space called the antrum forms, the follicle is an antral (tertiary) follicle. The mature, or Graafian, follicle is the large, ready-to-ovulate structure that releases the oocyte during ovulation. After ovulation, the remaining follicle tissue undergoes luteinization to form the corpus luteum, which secretes progesterone (and estrogen) to support early pregnancy. If pregnancy does not occur, the corpus luteum regresses to become the corpus albicans, a fibrous scar. Therefore, the sequence that correctly reflects this developmental order is primordial → primary → secondary → antral → mature → corpus luteum → corpus albicans.

Ovarian follicle development occurs in a numbered sequence that moves from a resting primordial follicle to progressively more mature structures, followed by ovulation and then luteal formation and eventual regression. A primordial follicle houses an oocyte arrested in prophase I and is encased by a single layer of flat granulosa cells. It matures into a primary follicle with a single layer of cuboidal granulosa cells and the beginnings of the zona pellucida. The next stage is the secondary (pre-antral) follicle, where granulosa cells proliferate and thecal cells start to appear. When a fluid-filled space called the antrum forms, the follicle is an antral (tertiary) follicle. The mature, or Graafian, follicle is the large, ready-to-ovulate structure that releases the oocyte during ovulation. After ovulation, the remaining follicle tissue undergoes luteinization to form the corpus luteum, which secretes progesterone (and estrogen) to support early pregnancy. If pregnancy does not occur, the corpus luteum regresses to become the corpus albicans, a fibrous scar.

Therefore, the sequence that correctly reflects this developmental order is primordial → primary → secondary → antral → mature → corpus luteum → corpus albicans.